Winona vs Midi vs Joi vs Josie: Finding the Best Menopause Treatment

  • Jelena Susic
  • March 22, 2025

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When I started experiencing menopause symptoms, I didn’t realize how much they would disrupt my daily life. My OBGYN wanted to run a series of tests before prescribing anything, but the process was slow and frustrating. I needed relief sooner. That’s when I started looking online for solutions and found four major brands: Winona, Josie, Joi, and Midi.

Each one offers something different, and after researching (and trying some of them myself), I figured out which is best depending on your needs. If you’re trying to decide on the right menopause treatment, this guide will help match you with the best option.

Quick Comparison of Winona vs MIDI vs Joi vs Josie

best for Fast HRT Approval

Winona

Winona is an online HRT provider known for fast approval and a supportive online community.

  • No insurance required; fast online approval
  • Customized hormone therapy shipped to your door
  • Ideal for women who want quick symptom relief
Best for Personalized GLP-1

Join Josie

Josie is a menopause-focused GLP-1 provider that helps women manage weight gain with compounded medications.

  • Compounded GLP-1 medications designed for midlife women
  • Appetite control and sustainable weight loss
  • Great if you're struggling with weight during perimenopause or menopause
Best for HRT With Insurance

Midi

Midi is a virtual menopause clinic that works with insurance to deliver ongoing HRT and symptom care.

  • Works with most major insurance providers
  • Offers full-spectrum menopause care
  • Perfect if you want your treatment covered by insurance
Best for at-home Testing & Personalized HRT

Joi

Joi is a women’s health platform that offers at-home hormone testing and personalized HRT plans.

  • Offers at-home hormone testing kits
  • Creates HRT plans tailored to your lab results
  • Ideal for women who want data-driven treatment

Why I Looked for an Online Solution

My menopause symptoms started creeping in earlier this year—hot flashes, brain fog, and mood swings. My biggest struggle? The sudden weight gain. No matter how well I ate or how much I exercised, my body wasn’t responding the same way.

When I asked my OBGYN about solutions, she suggested testing my hormone levels before considering HRT. That meant multiple appointments, lab visits, and waiting for results. Meanwhile, my symptoms weren’t getting any better.

I wanted answers and relief now, so I decided to explore online options. That’s when I found Winona, Josie, Joi, and Midi, four companies offering menopause treatments without the hassle of in-person doctor visits.

Winona: Best for Fast, Affordable HRT Without Insurance

winona hrt

I started with Winona because I wanted hormone replacement therapy (HRT) without jumping through insurance hoops. Their process was refreshingly simple: I filled out a questionnaire, and within hours, a doctor reviewed my case and prescribed HRT customized to my needs.

What I Liked:

  • Fast approval process (same day)
  • No insurance required
  • Customized hormone therapy shipped to my door
  • Noticeable symptom relief within weeks

Who Should Consider Winona?

If you don’t have insurance or want a fast, no-hassle way to get HRT, Winona is the best choice.


Josie: Best for Compounded GLP-1 for Menopause

josie weight loss

While HRT helped me manage my symptoms, I was still struggling with weight gain. That’s when I found Josie, a company that specializes in compounded GLP-1 medications designed for menopause.

I started Josie’s program and noticed a big difference in my hunger levels. I wasn’t constantly fighting cravings, and the scale finally started moving in the right direction.

After completing their assessment form, their medical team recommended compounded semaglutide for my situation. It took about a day for the doctor to approve it, but once approved, the medication shipped pretty fast.

Whoever they use for a compounding pharmacy - they do an excellent job because the stuff works. And, after doing a bunch of research into GLP-1 providers, I was skeptical of how the medication would be mixed.

After six months using Josie, I ended up losing 23 pounds and feeling more like myself again. I shared my full experience—including how I got started, what the injections were like, and what surprised me—inside my honest Join Josie review.

What I Liked:

  • Compounded GLP-1 tailored for menopause
  • Fast approval process, great shipping times
  • Appetite control and weight loss support
  • Simple process with an online consultation

Who Should Consider Josie?

If menopause weight gain is your biggest struggle, Josie’s compounded GLP-1 medication is a great solution.


Joi: Best for At-Home Hormone Testing & Personalized HRT

joi hrt

Joi stood out because they offer at-home hormone testing, which means you don’t have to guess what’s happening with your body. Their test gives a full picture of your hormone levels, and their doctors create a personalized HRT plan based on your results.

I loved the idea of having real data before starting treatment. If I had done this before Winona, I might have chosen Joi first!

What I Liked:

  • At-home hormone test for clear insights
  • Personalized HRT plan based on lab results
  • Great option for women who want a data-driven approach
  • Joi accepts insurance, which is great for those who have coverage - I did not, so it did not apply to me.

Who Should Consider Joi?

If you want a full picture of your hormones before starting HRT, Joi is the best option.


Midi: Best for HRT if You Have Insurance Coverage

midi hrt

While Winona is great for women without insurance, Midi is ideal if you want HRT covered by insurance. They work with most major providers, making it an affordable choice if you have coverage.

Since I didn’t want to go through insurance, I didn’t try Midi myself, but I did my research, and it’s highly rated.

One of the main differences that sets MIDI apart from Winona, Josie and Joi, is that MIDI makes you go through the ringer with the approval process, whereas the other brands will approve you faster.

What I Liked:

  • Accepts most insurance plans
  • Full-service menopause care
  • Great for women who want to use their benefits
  • Rigorous approval process, showing trust in their medical team

Who Should Consider Midi?

If you have insurance and want HRT covered, Midi is the way to go.


Final Thoughts

Menopause is tough, but having the right treatment makes all the difference. For me, Winona worked best for HRT, and Josie was a game-changer for weight loss. However, depending on your needs, Joi and Midi might be better options.

If you’re struggling to find the right menopause treatment, I hope my experience helps you make an informed decision. Whatever you choose, know that relief is out there!

Quick recap of which brand is for who:

Additional Resources


Jelena is a Registered Nurse with experience in Critical Care based in PNW. She enjoys traveling with her husband and son, hiking, camping and gardening. Her personal interests are maintaining health, strength and mobility into old age.

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